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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MARK2
All Species:
18.18
Human Site:
Y351
Identified Species:
33.33
UniProt:
Q7KZI7
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7KZI7
NP_001034558.2
788
87911
Y351
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
Chimpanzee
Pan troglodytes
XP_001172839
796
89049
Y358
D
A
L
I
N
Q
K
Y
D
E
V
M
A
T
Y
Rhesus Macaque
Macaca mulatta
XP_001115591
788
87964
Y351
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
Dog
Lupus familis
XP_540890
798
88683
R370
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Cat
Felis silvestris
Mouse
Mus musculus
Q05512
776
86287
G348
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
Rat
Rattus norvegicus
O08679
722
80853
I298
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511751
793
88836
Y357
E
S
L
I
N
Q
K
Y
N
E
V
M
A
T
Y
Chicken
Gallus gallus
Q9IA88
798
88848
L352
K
E
Y
R
S
S
Q
L
S
S
R
P
A
T
G
Frog
Xenopus laevis
NP_001080425
785
87931
Y355
D
S
L
V
N
Q
K
Y
N
E
V
M
A
T
Y
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
Y446
S
P
E
A
M
A
R
Y
L
S
M
R
R
H
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
K468
A
I
L
E
S
V
E
K
E
K
F
E
D
I
H
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
I87
I
I
R
Q
Y
E
V
I
E
T
T
S
D
I
Y
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
K209
M
T
D
G
N
F
L
K
T
S
C
G
S
P
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
68.2
99.7
95.1
N.A.
96.6
89.9
N.A.
68.4
30.3
84.3
27.5
N.A.
N.A.
N.A.
38.8
N.A.
Protein Similarity:
100
80.4
99.7
96.2
N.A.
97.7
90.9
N.A.
80.5
48.7
91.7
42.7
N.A.
N.A.
N.A.
49.9
N.A.
P-Site Identity:
100
66.6
100
0
N.A.
0
0
N.A.
73.3
13.3
86.6
13.3
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
93.3
100
20
N.A.
6.6
20
N.A.
93.3
26.6
93.3
20
N.A.
N.A.
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
26.5
27.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.1
45.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
8
0
8
0
0
0
0
0
0
47
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% C
% Asp:
31
8
8
8
0
0
0
0
8
0
8
0
16
0
0
% D
% Glu:
16
8
8
8
0
16
8
0
16
39
8
8
8
0
0
% E
% Phe:
0
0
0
0
0
8
0
0
0
0
8
0
0
0
0
% F
% Gly:
0
0
8
8
16
8
0
8
0
0
0
8
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% H
% Ile:
8
24
0
16
0
0
0
16
0
0
0
0
0
16
0
% I
% Lys:
16
0
0
0
0
0
24
16
0
16
0
0
0
0
0
% K
% Leu:
0
0
47
8
8
8
8
8
8
0
0
0
0
0
0
% L
% Met:
8
0
0
0
8
0
0
0
8
0
8
39
8
8
8
% M
% Asn:
0
0
0
0
31
0
0
0
31
8
0
8
0
0
16
% N
% Pro:
0
8
0
0
0
0
0
0
0
0
0
8
0
8
0
% P
% Gln:
8
0
8
8
0
39
24
0
8
0
0
0
0
0
0
% Q
% Arg:
0
8
8
8
0
0
24
8
0
8
8
16
8
0
0
% R
% Ser:
8
31
8
0
24
8
0
0
8
24
0
8
8
0
0
% S
% Thr:
0
8
0
8
0
0
0
0
8
8
8
0
0
47
16
% T
% Val:
0
0
0
24
8
8
16
0
0
0
39
8
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
0
8
0
8
0
0
47
8
0
8
0
0
0
47
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _